CGM 第190期：植物生殖细胞系中的表观遗传重编程
（Xiaoqi Feng）, University of Oxford ,PhD (2006-2010), UC Berkeley, Postdoc (2011-2014), John Innes Centre, Group Leader (2014- )
生殖细胞能够跨世代持续传递，其身份和延续需要对染色质状态进行广泛重编程。理解这一过程既有助于阐明生殖系生物学，也能解释表观遗传信息如何在经历大规模变化后完成继承。冯小琦实验室以拟南芥雄性生殖系的四类细胞为模型，建立细胞分离和表观基因组分析技术。借助逐类观察生殖细胞以及拟南芥对表观遗传扰动的较高耐受性，研究团队希望解析植物生殖系表观遗传重编程的范围、机制与生物学意义。
参考文献
Long J, Walker J, She W, Aldridge B, Gao H, Deans S, Feng X. (2021) Nurse cell-derived small RNAs define paternal epigenetic inheritance in Arabidopsis. Science 373: eabh0556
He S, Vickers M, Zhang J, Feng X. (2019) Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation. eLife 8: e42530
Walker J, Gao H, Zhang J, Aldridge B, Vickers M, Higgins JD, Feng X. (2018) Sexual lineage specific DNA methylation regulates Arabidopsis meiosis. Nature Genetics 50: 130-137
Hsieh PH, He S, Buttress T, Gao H, Couchman M, Fischer RL, Zilberman D, Feng X. (2016) Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues. PNAS 113: 15132-15137
评论（0）
登录后即可发表评论。
登录暂无评论，来发表第一条评论吧！